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Ailments are negative medical or psychological conditions that can affect survivors in Sheltered 2. Some are holdovers from Sheltered (the original 2016 release), whereas others are new entirely. Even if an ailment did exist in Sheltered then it may have a different remedy in Sheltered 2 than in its predecessor.

Ailments can be subdivided into physical and mental ailments. Examples of physical ailments include missing teeth, broken limbs, heat exhaustion, etc., and they tend to affect physical attributes (Strength, Dexterity, and Fortitude, mainly). Examples of mental ailments include depression (more to be added later), and tend to affect mental attributes (Charisma, Perception, and Intelligence).

Some physical ailments require a second survivor with the requisite "Surgeon" skill as well as a Medical Bed in order to heal (thus making the prerequisites to heal those ailments an Intelligence level of >10 on the healer character as well as having discovered/added the blueprint for the medical bed).

Likewise, some mental ailments require the "Therapy" skill, as well as a medical bed to heal (thus making the prerequisites to heal those ailments a Charisma level of >10 on the healer character as well as having discovered/added the blueprint for the medical bed).

Below is a partial list of ailments, how they are obtained as well as their effects and the recommended treatment.

Physical Ailments

Ailment Obtained by Effect Treatment
Weakened Heart Reviving a character via CPR or Defibrilator Sluggish, cannot be revived if unconscious Time elapse (approximately 2-4 weeks)
Slipped Disc Combat -5 STR, -2 DEX Surgery skill
Radiation Poisoning Radiation (being outside shelter in black rain/sandstorm) Sluggish, Health drain, occasionally vomiting Anti-Radiation Tablets (instant), Time Elapse (-1HP per 1Rad metabolised)
Malnutrition Allowing food bar to go all the way to full (100% red) Sluggish, Health drain, decreased mood Food
Food Poisoning Eating spoiled food, eating with high dirtiness stat (chance) Sluggish, Health drain, occasional vomiting Antiemetic, Time elapse
Facial Disfigurement Combat, Failed experimentation -10 Charisma Surgery
Deaf Combat, Failed experimentation -4 Perception, -2 Charisma Surgery
Missing Teeth Combat, Failed experimentation Unknown Surgery
Damaged Lungs Failed Experimentation, Fire -2 Fortitude, -5 Dexterity Surgery
Tennis Elbow Failed Experimentation -2 Strength Surgery
Shock Failed Experimentation, Trauma? -2 Intelligence, -2 Perception Therapy

Mental Ailments

Ailment Obtained by Effect Treatment
Insomnia Mental breakdowns, Failed experimentation -5 perception, -50 stamina Therapy
Claustrophobia Mental breakdowns, Failed experimentation Character develops negative mood modifier when in small spaces Therapy
Astraphobia Mental breakdowns, Failed experimentation Character develops negative mood modifier during thunderstorms Therapy
Nyctophobia Mental breakdowns, Failed experimentation Character develops negative mood modifier when in dark spaces Therapy
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